The Development of Electroconvulsive Device for Anti- Convulsion Drug Trials

A Low cost electroconvulsive device is developed to evoke artificial convulsions in mice for anti-convulsion drug trials. The device is expected to consume not more than 70 Watts of electric power supply and to produce single burst of pulses of electric voltage or current through its corneal electrodes when its foot pedal is pressed. The output specifications are 0.1 to 1 second of burst duration, 10 to 100 Hertz of pulse frequency, 0.5 to 20 milliseconds of pulse width and 0 to 200 Volts or milliamperes of amplitude of electric voltage or current. The electroconvulsive device is built from several blocks of electronic circuits which exploit the features of popular and low cost 555 timer and low offset OP07 op-amp Integrated circuits. The experiments show that the device has met the specifications and been able to evoke artificial convulsions in 20 to 22 grams of mice at 0.2 seconds of burst duration, 100 Hertz of pulse frequency, 0.5 milliseconds of pulse-width and 25 to 35 milliamperes of amplitude of electric current of output signal’s parameters.

Dibuat oleh : Andre Widura, Djafri  & Sugiarto Puradisastra (andre.widura@itenas.ac.i,  sugiarto.puradisastra@med.maranatha.edu)

Kata Kunci :  Anti-convulsion, artificial convulsion, electroconvulsive, evoking artificial convulsion.

The Development of Electroconvulsive Device for Anti- Convulsion Drug Trials